Complete recovery from anxiety disorders following Cognitive Behavioural Therapy in children and adolescents: a meta analysis

Cognitive Behavior Therapy (CBT) is a well-established treatment for childhood anxiety disorders. Meta-analyses have concluded that approximately 60% of children recover following treatment, however these include studies using a broad range of diagnostic indices to assess outcomes including whether children are free of the one anxiety disorder that causes most interference (i.e. the primary anxiety disorder) or whether children are free of all anxiety disorders. We conducted a meta-analysis to establish the efficacy of CBT in terms of absence of all anxiety disorders. Where available we compared this rate to outcomes based on absence of primary disorder. Of 56 published randomized controlled trials, 19 provided data on recovery from all anxiety disorders (n = 635 CBT, n = 450 control participants). There was significant heterogeneity across those studies with available data and full recovery rates varied from 47.6 to 66.4% among children without autistic spectrum conditions (ASC) and 12.2 to 36.7% for children with ASC following treatment, compared to up to 20.6% and 21.3% recovery in waitlist and active treatment comparisons. The lack of consistency in diagnostic outcomes highlights the urgent need for consensus on reporting in future RCTs of childhood anxiety disorders for the meaningful synthesis of data going forwards

Large scale surveys at 408 MHz.

Since the very early days of Radio Astronomy, much work has been done towards measuring the large scale structure of the galactic radio continuum radiation. However, in recent years, owing to the advent of short centimeter wave receivers on large dishes, and the techniques of aperture synthesis, interest has turned to studying fairly small regions of the sky, with the highest possible resolution. The result has been that many questions pertaining to the large scale structure of our galaxy, particularly at high galactic latitudes, have remained unanswered. There is still much work to be done in this field, but when one examines the observational evidence avail— able, a glaring omissiOn is apparent. There exists no complete, consistent survey of the whole sky with a resolution suitable for the study of the structure of the high latitude galactic radio radiation. This thesis describes steps that have been made, and are being made, to provide such a survey

Powerful Water Masers in Active Galactic Nuclei

Luminous water maser emission in the 6_(16)-5_(23) line at 22 GHz has been detected from two dozen galaxies. In all cases the emission is confined to the nucleus and has been found only in AGN, in particular, in Type 2 Seyferts and LINERs. I argue that most of the observed megamaser sources are powered by X-ray irradiation of dense gas by the central engine. After briefly reviewing the physics of these X-Ray Dissociation Regions, I discuss in detail the observations of the maser disk in NGC 4258, its implications, and compare alternative models for the maser emission. I then discuss the observations of the other sources that have been imaged with VLBI to date, and how they do or do not fit into the framework of a thin, rotating disk, as in NGC 4258. Finally, I briefly discuss future prospects, especially the possibility of detecting other water maser transitions.Comment: 45 pages, 16 figures. Refereed and greatly expanded version of my review talk at the ASA meeting in Lorne, July 2001. To appear in Proceedings of the Astronomical Society of Australi

Soft X-ray emission from the inner disk of M33

We present a study, based on archival XMM-Newton observations, of the extended X-ray emission associated with the inner disk of M33. After the exclusion of point sources with L_X > 2 x 10^{35} erg/s (0.3-6 keV), we investigate the morphology and spectrum of the residual X-ray emission. This residual emission has a soft X-ray spectrum which can be fitted with a two-temperature thermal model, with kT = 0.2 keV and 0.6 keV. The soft X-ray surface brightness distribution shows a strong correlation with FUV emission, indicative of a close connection between recent star-formation activity and the production of soft X-rays. Within 3.5 kpc of the nucleus of M33, the soft X-ray and FUV surface brightness distributions exhibit similar radial profiles. This implies that the ratio of the soft X-ray luminosity (0.3-2.0 keV) to the star formation rate (SFR) per unit disk area remains fairly constant within this inner disk region. We derive a value for this ratio of 1-1.5 x 10^{39} (erg/s)/(M_sun/yr), consistent with previous studies. In the same region, the ratio of soft X-ray luminosity to stellar mass (derived from K-band photometry) is 4 x 10^{28} erg/s/M_sun, a factor of 5-10 higher than is typical of dwarf elliptical galaxies, suggesting that 10-20% of the unresolved emission seen in M33 may originate in its old stellar population. The remainder of the soft X-ray emission is equally split between two spatial components, one which closely traces the spiral arms of the galaxy and the other more smoothly distributed across the inner disk of M33. The former must represent a highly clumped low-filling factor component linked to sites of recent or ongoing star formation, whereas the distribution of the latter gives few clues as to its exact origin.Comment: 13 pages, 4 figures, 5 tables. Accepted for publication in MNRA

Guidelines and considerations for the use of system suitability and quality control samples in mass spectrometry assays applied in untargeted clinical metabolomic studies

Background Quality assurance (QA) and quality control (QC) are two quality management processes that are integral to the success of metabolomics including their application for the acquisition of high quality data in any high-throughput analytical chemistry laboratory. QA defines all the planned and systematic activities implemented before samples are collected, to provide confidence that a subsequent analytical process will fulfil predetermined requirements for quality. QC can be defined as the operational techniques and activities used to measure and report these quality requirements after data acquisition. Aim of review This tutorial review will guide the reader through the use of system suitability and QC samples, why these samples should be applied and how the quality of data can be reported. Key scientific concepts of review System suitability samples are applied to assess the operation and lack of contamination of the analytical platform prior to sample analysis. Isotopically-labelled internal standards are applied to assess system stability for each sample analysed. Pooled QC samples are applied to condition the analytical platform, perform intra-study reproducibility measurements (QC) and to correct mathematically for systematic errors. Standard reference materials and long-term reference QC samples are applied for inter-study and inter-laboratory assessment of data

The properties of extragalactic radio sources selected at 20 GHz

We present some first results on the variability, polarization and general properties of radio sources selected in a blind survey at 20 GHz, the highest frequency at which a sensitive radio survey has been carried out over a large area of sky. Sources with flux densities above 100 mJy in the AT20G Pilot Survey at declination -60 to -70 were observed at up to three epochs during 2002-4, including near-simultaneous measurements at 5, 8 and 18 GHz in 2003. Of the 173 sources detected, 65% are candidate QSOs, BL Lac objects or blazars, 20% galaxies and 15% faint (b > 22 mag) optical objects or blank fields. On a 1-2 year timescale, the general level of variability at 20 GHz appears to be low. For the 108 sources with good-quality measurements in both 2003 and 2004, the median variability index at 20 GHz was 6.9% and only five sources varied by more than 30% in flux density. Most sources in our sample show low levels of linear polarization (typically 1-5%), with a median fractional polarization of 2.3% at 20 GHz. There is a trend for fainter sources to show higher fractional polarization. At least 40% of sources selected at 20GHz have strong spectral curvature over the frequency range 1-20 GHz. We use a radio `two-colour diagram' to characterize the radio spectra of our sample, and confirm that the radio-source population at 20 GHz (which is also the foreground point-source population for CMB anisotropy experiments like WMAP and Planck) cannot be reliably predicted by extrapolating the results of surveys at lower frequencies. As a result, direct selection at 20 GHz appears to be a more efficient way of identifying 90 GHz phase calibrators for ALMA than the currently-proposed technique of extrapolation from all-sky surveys at 1-5 GHz.Comment: 14-page paper plus 5-page data table. Replaced with published versio

Cupá, ou cipó-babão, alimento de alguns índios amazônicos

INPA is developing studies concerning the agricultural plants of the Brazilian Indians. a collection was made among the Kayapó Indians of the Cupa vine (Cissus gongylodes Burch. ex Baker, Vitaceae). This note provides botanical information on this plant, its uses by the seringueiros (rubber collectors) and by the indians, and agronomical and chemical data

Digital video interventions and mental health literacy among young people: a scoping review

Background: Mental health literacy is important as it relates to understanding mental illness, increasing help-seeking efficacy, and reducing mental illness-related stigma. One method to improve the mental health literacy of young people is a digital video intervention. Aims: A scoping review was conducted to map existing research in the area of digital video interventions for mental health literacy among young people. Methods: The scoping review was conducted following the PRISMA-ScR checklist. All results were screened based on our inclusion criteria. Results: Seventeen studies were selected for analysis. In most studies (n = 14), a digital video was the only intervention whereas three studies took a multi-intervention approach. Only two of the digital video interventions were co-created with people with mental illness or university students. All studies showed positive results in favor of digital video interventions in at least one component of mental health literacy or compared to one of the comparison conditions. Conclusions: Digital video interventions represent effective tools for enhancing mental health literacy. However, there is a need for active involvement of end-users in co-creation and to attend to the production quality so that the digital video intervention is as relevant, informed, and effective as possible

NGC 7582: The Prototype Narrow-Line X-ray Galaxy

NGC 7582 is a candidate prototype of the Narrow Line X-ray Galaxies (NLXGs) found in deep X-ray surveys. An ASCA observation shows the hard (> 3 keV) X-ray continuum of NGC 7582 drops 40% in ~6 ks, implying an AGN, while the soft band (< 3 keV) does not drop in concert with the hard continuum, requiring a separate component. The X-ray spectrum of NGC 7582 also shows a clear 0.5-2 keV soft (kT = 0.8 (+0.9,-0.3) keV or Gamma = 2.4 +/- 0.6; L(X) = 6 x 10**40 ergs s**-1) low--energy component, in addition to a heavily absorbed [N(H) = (6 +/- 2)\times 10**22 cm**-2 ] and variable 2-10 keV power law [Gamma = 0.7 (+0.3,-0.4); L(X) = (1.7-2.3) x 10**42 ergs s**-1]. This is one of the flattest 2-10 keV slopes in any AGN observed with ASCA. (The ROSAT HRI image of NGC 7582 further suggests extent to the SE.) These observations make it clear that the hard X-ray emission of NGC 7582, the most "narrow-line" of the NLXGs, is associated with an AGN. The strong suggestion is that all NLXGs are obscured AGNs, as hypothesized to explain the X-ray background spectral paradox. The separate soft X-ray component makes NGC 7582 (and by extension other NLXGs) detectable as a ROSAT source.Comment: text: Latex2e 10 pages, including 1 table, and 2 postscript figures via psfi